Here is a potential crypto investment strategy for a $100,000 portfolio:

1. Diversification: Allocate your portfolio across different cryptocurrencies to spread the risk. Consider investing in a mix of established cryptocurrencies like Bitcoin and Ethereum, as well as some promising altcoins with strong fundamentals.

2. Core Holdings: Allocate a significant portion of your portfolio (around 50-60%) to core holdings like Bitcoin and Ethereum. These are considered the most stable and widely adopted cryptocurrencies, providing a solid foundation for your portfolio.

3. Mid-cap Altcoins: Allocate around 20-30% of your portfolio to mid-cap altcoins. These are cryptocurrencies with a market capitalization between $1 billion and $10 billion. Look for projects with innovative technology, strong teams, and a clear use case. Conduct thorough research before investing in any altcoin.

4. Small-cap Altcoins: Allocate around 10-20% of your portfolio to small-cap altcoins. These are cryptocurrencies with a market capitalization below $1 billion. Investing in small-cap altcoins can be riskier but also potentially more rewarding. Look for projects with unique features, partnerships, and a solid roadmap.

5. Risk Management: Set stop-loss orders to protect your portfolio from significant losses. Determine an acceptable level of risk for your portfolio and stick to it. Consider rebalancing your portfolio periodically to maintain the desired allocation.

6. Dollar-Cost Averaging: Instead of investing the entire $100,000 at once, consider using a dollar-cost averaging strategy. This involves investing a fixed amount at regular intervals (e.g., monthly) regardless of the cryptocurrency's price. This strategy helps mitigate the impact of short-term volatility.

7. Stay Informed: Keep up with the latest news, developments, and market trends in the cryptocurrency space. Join reputable communities, follow influential figures, and stay updated on regulatory changes. This will help you make informed investment decisions.

8. Long-Term Perspective: Cryptocurrency markets can be highly volatile, so it's important to have a long-term perspective. Avoid making impulsive decisions based on short-term price fluctuations. Stick to your investment strategy and evaluate its performance over the long run.

Remember, this is just one potential strategy, and it's crucial to do your own research and consult with a financial advisor before making any investment decisions.